MR venography in children and adolescents with multiple sclerosis does not show increased prevalence of extracranial veins anomalies.
PBN-AR
Instytucja
Instytut "Pomnik - Centrum Zdrowia Dziecka"
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
ISSN
1090-3798
EISSN
Wydawca
ELSEVIER SCI LTD
DOI
URL
Rok publikacji
2014
Numer zeszytu
2
Strony od-do
218-222
Numer tomu
18
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
multiple sclerosis
children
magnetic resonance imaging
MR venography
chronic cerebrospinal venous insufficiency
Streszczenia
Język
angielski
Treść
BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system that affects mainly young adults, but can occur also in children and adolescents. The pathogenesis of MS is still not fully understood and chronic cerebrospinal venous insufficiency (CCSVI) was suggested to be implicated in MS. Although there is no strong evidence to support this hypothesis, a considerable number of MS patients, including adolescents, have undergone endovascular treatment procedures. The aim of this study was the evaluate the prevalence of extracranial venous system anomalies in children and adolescents with multiple sclerosis in comparison to age-matched controls. MATERIAL AND METHODS: Twenty-one children with clinically definite diagnosis of MS (mean age 13.8 years), and 19 age-matched controls (mean age 12.5 years) were investigated using 1.5 T scanner with coronal 3D contrast-enhanced coronal venography. The diameters of internal jugular veins (IJV) at both sides of the neck were estimated separately, from the level C1 to Th1. RESULTS: Anomalies of the extracranial venous system were found in 10 MS patients (47.6%) and 13 controls (68.4%). Normal anatomy of extracranial veins was recognized in 11 MS patients (53%) and 6 controls (31%). Comparison of the measurement results for MS patients and the control group revealed that there are no significant statistical differences in cross-section areas for a given level. CONCLUSIONS: We found no evidence to suggest that MS children and adolescents have more extracranial veins anomalies than healthy patients. Considering the risk of such treatment, endovascular interventions should be discourage.
Cechy publikacji
Original-article
Inne
System-identifier
0000013176
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