Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer
PBN-AR
Instytucja
Wydział Lekarski Kształcenia Podyplomowego (Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu)
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Human Immunology
ISSN
0198-8859
EISSN
Wydawca
ELSEVIER SCIENCE INC
DOI
URL
Rok publikacji
2014
Numer zeszytu
6
Strony od-do
508-513
Numer tomu
75
Link do pełnego tekstu
Identyfikator DOI
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Słowa kluczowe
en
Ovarian cancer
Killer immunoglobulin-like receptor
Human leukocyte antigen
KIR2DS4
NK cells
Streszczenia
Język
en
Treść
Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic.In this study we analyzed associations of KIR and KIR ligand genes with the incidence and clinical course of epithelial ovarian cancer. DNA of 142 patients was analyzed for KIR genes and 103 samples were typed for HLA class I. Control group consisted of 200 healthy individuals, including 83 women, analyzed separately. The frequency of KIR genes in patients and controls were comparable. HLA-C group 1 (ligand for KIR2DL2/3) was more frequent in patients than in controls (86.4% vs. 67.5%, p=0.002). The frequency of KIR2DS4fl was higher in patients with endometrioid cancer (72.3%) compared with other histological subtypes (36.5%, p=0.004) and controls (29.5%, p=0.0001). KIR and KIR ligand genotype did not influence significantly the clinical course of the disease.We conclude that the genotype of KIR ligands is strongly associated with the incidence of epithelial ovarian cancer while KIR2DS4fl confers susceptibility to endometrioid subtype of the disease.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
457184
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