Effect of a carbonated HAP/$\beta$-glucan composite bone substitute on healing of drilled bone voids in the proximal tibial metaphysis of rabbits
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Materials Science and Engineering. C, Materials for Biological Applications
ISSN
0928-4931
EISSN
1873-0191
Wydawca
Elsevier Science BV
Rok publikacji
2015
Numer zeszytu
Strony od-do
60--67
Numer tomu
53
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.5
Słowa kluczowe
EN
bone
composite
mineralization
implantation
rabbit
osseointegration
Streszczenia
Język
EN
Treść
A novel elastic hydroxyapatite-based composite of high surgical handiness has been developed. Its potential application in orthopedics as a filler of bone defects has been studied. The biomaterial was composed of carbonated hydroxyapatite (CHAP) granules and polysaccharide polymer (beta-1,3-glucan). Cylinders of 4 mm in diameter and 6 mm in length were implanted into bone cavities created in the proximal metaphysis of tibiae of 24 New Zealand white rabbits. 18 sham-operated animals were used as controls. After 1, 3 or 6 months, the rabbits were euthanized, the bones were harvested and subjected to analysis. Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. Peripheral quantitative computed tomography (pQCT) indicated the stimulating effect of the biomaterial on bone formation and mineralization. Densitometry (DXA) analysis suggested that biomineralization of bones was preceded by bioresorption and gradual disappearance of porous ceramic granules. The findings suggest that the CHAP-glucan composite material enables regeneration of bone tissue and could serve as a bone defect filler. (C) 2015 Elsevier B.V. All rights reserved.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:095718
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