Small regulatory RNAs in lambdoid bacteriophages and phage-derived plasmids: not only antisense.
PBN-AR
Instytucja
Instytut Biochemii i Biofizyki Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Plasmid
ISSN
0147-619X
EISSN
Wydawca
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI
Rok publikacji
2015
Numer zeszytu
Strony od-do
71-78
Numer tomu
78
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
EN
DNA replication regulation;
Enterohemorrhagic Escherichia coli;
Lambdoid bacteriophages;
oop RNA;
p(aQ) promoter
Streszczenia
Język
EN
Treść
Until recently, only two small regulatory RNAs encoded by lambdoid bacteriophages were known. These transcripts are derived from paQ and pO promoters. The former one is supposed to act as an antisense RNA for expression of the Q gene, encoding a transcription antitermination protein. The latter transcript, called oop RNA, was initially proposed to have a double role, in establishing expression of the cI gene and in providing a primer for DNA replication. Although the initially proposed mechanisms by which oop RNA could influence the choice between two alternative developmental pathways of the phage and the initiation of phage DNA replication were found not true, the pO promoter has been demonstrated to be important for both regulation of phage development and control of DNA replication. Namely, the pO-derived transcript is an antisense RNA for expression of the cII gene, and pO is a part of a dual promoter system responsible for regulation of initiation of DNA synthesis from the oriλ region. Very recent studies identified a battery of small RNAs encoded by lambdoid bacteriophages existing as prophages in chromosomes of enterohemorrhagic Escherichia coli strains. Some of them have very interesting functions, like anti-small RNAs.
Cechy publikacji
Article
Inne
System-identifier
PX-56b476898106eb71826ee7bb
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