Synthesis and Comprehensive Structural and Chiroptical Characterization of Enones Derived from (−)-α-Santonin by Experiment and Theory
PBN-AR
Instytucja
Instytut Chemii Organicznej Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF ORGANIC CHEMISTRY
ISSN
0022-3263
EISSN
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2016
Numer zeszytu
11
Strony od-do
4588-4600
Numer tomu
81
Identyfikator DOI
Liczba arkuszy
Streszczenia
Język
angielski
Treść
The aim of the present work is to explain the causes of the observed deviations from sector and helicity rules to determine the absolute configuration of optically active α,β-unsaturated ketones by means of electronic circular dichroism (ECD). To this end, a series of model compounds with a common decahydronaphthalene skeleton representing both cisoid and transoid enones were synthesized. In the framework of this work, detailed dichroic studies supported by single crystal X-ray analysis were performed where possible. To assist the achievement of the desired objectives the conformational flexibility of the selected cis-enones through the dependence of solvent and temperature on the ECD spectra were examined. All experimental studies were supplemented by detailed DFT calculations. A notable result of the study is assessing the applicability of the enone sector and helicity rules in dichroic studies and potential restrictions. To this end, a number of factors that could determine the signs of the individual Cotton effects has been considered. Among these nonminimum structure effects, i.e., twisting of the enone chromophore and nonplanarity of the enone double bond can be mentioned.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
740060
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