Monitoring the Interfacial Behavior of Selective Y5 Receptor Antagonist on Colloidal Gold Nanoparticle Surfaces: Surface-Enhanced Vibrational Spectroscopy Studies
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Physical Chemistry C (35pkt w roku publikacji)
ISSN
1932-7447
EISSN
1932-7455
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2017
Numer zeszytu
32
Strony od-do
17276–17288
Numer tomu
121
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
DENSITY-FUNCTIONAL THEORY
NEUROPEPTIDE-Y
INFRARED-SPECTROSCOPY
RAMAN-SCATTERING
NERVOUS-SYSTEM
LU AA33810; SERS
ABSORPTION
SPECTRA
MOLECULES
Streszczenia
Język
en
Treść
This report describes the first detailed characterization of the molecular structure of Lu AA33810, a selective Y5 receptor antagonist, and its behavior at the solid/liquid interface after conjugation with gold nanoparticles (GNPs). Physicochemical characterization, including imaging by scanning electron microscopy as well as electrophoretic mobility and dynamic light scattering measurements, was performed to determine the morphology, electrokinetic properties and range of stability of the GNPs. A comprehensive vibrational analysis, employing Raman spectroscopy, Fourier transform infrared absorption, surface-enhanced Raman spectroscopy, and surface-enhanced infrared absorption methods, is reported. The experimental data are supported by density functional theory calculations. It is implied that the Thz and Phe rings determine the adsorption geometry of Lu AA33810 on the studied GNPs and adopt a tilted orientation, exposing the interaction between the Thz free electron pair and the metallic nanosubstrates. The analysis also provides evidence for strong interaction between the free electron pairs located on the oxygen atoms of the SO2 fragment of methanesulfonamide and the GNPs. The results provide important insight into designing new compounds with agonistic or antagonistic properties toward the Y5 receptor.
Inne
System-identifier
PX-5a7c2138d5de3cc73762ac8c
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