Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Geriatrics & Gerontology International
ISSN
1444-1586
EISSN
1447-0594
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2015
Numer zeszytu
3
Strony od-do
365-371
Numer tomu
15
Identyfikator DOI
Liczba arkuszy
0,71
Słowa kluczowe
en
free leptin index
healthy aging
leptin
leptin receptor isoforms
Streszczenia
Język
en
Treść
Aim: Aging is usually associated with hyperleptinemia and leptin resistance, both increasing the risk of age-related diseases. It was relevant to establish if healthily aging, non-obese individuals develop changes in leptin, the soluble leptin receptor (OB-Re), free leptin index (FLI), in methylation of the leptin receptor gene (LEPR) promoter, and in the expression of long (OB-Rb) and short (OB-Ra) leptin receptor isoforms. Methods: We analyzed these parameters in 38 young (aged 26.8 +/- 3.6 years), 37 elderly (aged 64.7 +/- 3.1 years) and 39 long-lived (aged 94.2 +/- 3.7 years) healthy, non-obese Polish Caucasians. Results: In elderly men, the median concentration of leptin and the median FLI were significantly higher than in young men (P = 0.009 and P = 0.007, respectively), which was probably partly due to a higher mean body mass index of the elderly study participants. In peripheral blood mononuclear cells, the expression of functionally active OB-Rb did not depend on age or sex, whereas the expression of OB-Ra was lower in the elderly and long-lived groups than in the young group (P < 0.0001 and P = 0.002, respectively), mostly due to changes observed in women. Most likely, this age-related decrease was not due to hypermethylation of the LEPR promoter, as methylation of the +20 to +281 fragment of the CpG island did not change with age. Conclusions: In healthy, non-obese individuals, only some elements of the leptin axis slightly change with age. On that basis, we suggest that proper function of this axis might be required for this particular phenotype of aging. The present results should, however, be replicated in prospective studies and in other ethnic groups.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
629865
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