A Highly Sensitive Spectrophotometric Determination of Sodium 2Sulfanylethanesulfonate in Pharmaceutical Preparations
PBN-AR
Instytucja
Wydział Matematyki, Fizyki i Chemii (Uniwersytet Śląski w Katowicach)
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
JOURNAL OF ANALYTICAL CHEMISTRY
ISSN
1061-9348
EISSN
Wydawca
URL
Rok publikacji
2015
Numer zeszytu
7
Strony od-do
831-836
Numer tomu
70
Identyfikator DOI
Liczba arkuszy
0,3
Autorzy
Słowa kluczowe
EN
leucocrystal violet
mesna
pharmaceutical analysis
sodium 2-mercaptoethanesulfonate
sodium 2-sulfanylethanesulfonate
spectrophotometry
Streszczenia
Język
EN
Treść
The aim of this research was to develop a new sensitive and simple spectrophotometric method for the determination of sodium 2-sulfanylethanesulfonate (SSES) with leucocrystal violet. The procedure is based on a redox reaction occurring between the SSES and potassium iodate in an acidic medium. Formed in stoichiometric quantity iodine oxidizes leucocrystal violet to the crystal violet dye, whose coloring is a base of the spectrophotometric measurements. The crystal violet dye formed shows maximum and stable absorbance at pH = 4.1 ± 0.1 and λ = 590 nm. The molar absorptivity, limit of detection and limit of determination of the method were calculated to be 6.98 × 104 L/mol cm, 0.10 and 0.13 μg/mL, respectively. The color system obeys Beer’s law in the range 0.2–2.0 μg/mL of SSES. The optimum analytical conditions were evaluated. The proposed method has been successfully applied to the determination of SSES in pharmaceutical preparations, without the need of any complicated instrumentation. Reliability of determination was confirmed applying standard iodometric method, recommended by European and Polish Pharmacopoeia.
Inne
System-identifier
0192700125922
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