Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography
PBN-AR
Instytucja
Wydział Lekarski Kształcenia Podyplomowego (Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu)
Źródłowe zdarzenia ewaluacyjne
Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez Wydział Lekarski Kształcenia Podyplomowego) Usefulness of Somatostatin Receptor Scintigraphy (Tc - (HYNIC, Tyc3 – Octreotide ) and I-Metaiodobenzylguanidine Scintigraphy in Patients with SDHx Gene-Related Pheochromocytomas and Paragangliomas Detected by Computed Tomography (zgłoszony przez Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie) Usefulness of Somatostatin Receptor Scintigraphy (Tc-99m-[HYNIC, Tyr3]-Octreotide) and I-123-Metaiodobenzylguanidine Scintigraphy in Patients with SDHx Gene-Related Pheochromocytomas and Paragangliomas Detected by Computed Tomography (zgłoszony przez Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie) Usefulness of somatostatin receptor scintigraphy <SUP>99m</SUP>(Tc-[HYNIC, Tyr3]-Octreotide) and (<SUP>123</SUP>I-metaiodobenzylguanidine scintigraphy in patients with <I>SDHx</I> gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez Wydział Lekarski) Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-Octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez Instytut Kardiologii im. Prymasa Tysiąclecia Stefana Kardynała Wyszyńskiego) Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography. (zgłoszony przez Centrum Medyczne Kształcenia Podyplomowego w Warszawie) Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-Octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez Wydział Nauk Medycznych) Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3] – Octreotide) and 123 I-Metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez I Wydział Lekarski) Usefulness of somatostatin receptor scintigraphy (Tc-[HYNIC, Tyr3]-octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography. (zgłoszony przez Instytut "Pomnik - Centrum Zdrowia Dziecka") Usefulness of somatostatin receptor scintigraphy (99mTc-[HYNIC, Tyr3]-Octreotide) and 123I-metaiodobenzylguanidine scintigraphy in patients with SDHx gene-related pheochromocytomas and paragangliomas detected by computed tomography (zgłoszony przez Wydział Lekarski)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
NEUROENDOCRINOLOGY
ISSN
0028-3835
EISSN
Wydawca
KARGER
DOI
URL
Rok publikacji
2015
Numer zeszytu
4
Strony od-do
321-330
Numer tomu
101
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Somatostatin receptor scintigraphy · Metaiodobenzylguanidine · Computed tomography · Paraganglioma-pheochromocytoma syndromes · SDHx gene mutations
Streszczenia
Język
en
Treść
Abstract Aims: The aim of this study was to assess the usefulness of somatostatin receptor scintigraphy (SRS) using 99m Tc-[HYNIC, Tyr3]-octreotide (TOC) and 123 I-metaiodobenzylguanidine (mIBG) in patients with SDHx -related syndromes in which paragangliomas were detected by computed tomography and to establish an optimal imaging diagnostic algorithm in SDHx mutation carriers. Methods: All carriers with clinical and radiological findings suggesting paragangliomas were screened by SRS and 123 I-mIBG. Lesions were classified by body regions, i.e. head and neck, chest, abdomen with pelvis and adrenal gland as well as metastasis. Results: We evaluated 46 SDHx gene mutation carriers (32 index cases and 14 relatives; 28 SDHD , 16 SDHB and 2 SDHC ). In this group, 102 benign tumors were found in 39 studied patients, and malignant disease was diagnosed in 7 patients. In benign tumors, the sensitivity of SRS was estimated at 77% and of 123 I-mIBG at 22.0%. The SRS and mIBG sensitivity was found to be clearly region dependent (p < 0.001). The highest SRS sensitivity was found in head and neck paragangliomas (HNP; 91.4%) and the lowest was found in abdominal paragangliomas and pheochromocytomas (40 and 42.9%, respectively). The highest 123 I-mIBG sensitivity was found in pheochromocytomas (sensitivity of 100%) and the lowest in HNP (sensitivity of 3.7%). In metastatic disease, SRS was superior to mIBG (sensitivity of 95.2 vs. 23.8%, respectively). Conclusion: SRS and 123 I-mIBG single photon emission computed tomography (SPECT) sensitivity in SDHx patients is highly body region dependent. In malignant tumors, SRS is superior to 123 I-mIBG SPECT
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
694266
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