Solid-state stability and compatibility studies of clavulanate potassium
PBN-AR
Instytucja
Instytut Fizyki Molekularnej Polskiej Akademii Nauk
Źródłowe zdarzenia ewaluacyjne
Informacje podstawowe
Główny język publikacji
en
Czasopismo
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
ISSN
1083-7450
EISSN
Wydawca
INFORMA HEALTHCARE
DOI
URL
Rok publikacji
2015
Numer zeszytu
2
Strony od-do
146-152
Numer tomu
20
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
Streszczenia
Język
en
Treść
The kinetic and thermodynamic parameters of degradation of clavulanate potassium in the solid state were studied by using a reversed phase high performance liquid chromatography (RP-HPLC) method. The degradation of clavulanate potassium was a first-order reaction depending on the substrate concentration at an increased relative air humidity (RH) and in dry air. The dependence ln k = f(1/T) became the ln k = (0.026 +/- 166.35)-(2702.82 +/- 1779.43)(1/T) in dry air and ln k = (1.65 +/- 100.40) x 10(3)-(5748.81 +/- 3659.67)(1/T) at 76.4\% RH. The thermodynamic parameters E-a, Delta H-not equal a, Delta S-not equal a of the degradation of clavulanate potassium in the solid state were calculated. The dependence ln k = f (RH\%) assumed the form ln k = (8.78 +/- 5.75) 10(-2) (RH\%) + (2.64 x 10(-8) (+/-) 40.41). The compatibility of clavulanate potassium with commonly used excipients was studied at an increased temperature and in dry air. The geometric structure of molecule, highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) orbitals were also determined in order to predict the structural changes and reactive sites in clavulanate potassium during degradation and compatibility studies in the solid state. The ultraviolet (UV), Fourier transform infrared spectroscopy (FT-IR) and Raman spectra of degraded samples of the compound were analyzed.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
628218
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych