A proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties.
PBN-AR
Instytucja
Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
International Journal of Occupational Medicine and Environmental Health
ISSN
1232-1087
EISSN
Wydawca
DOI
URL
Rok publikacji
2014
Numer zeszytu
4
Strony od-do
627-640
Numer tomu
27
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Autorzy
(liczba autorów: 2)
Słowa kluczowe
PL
związki organiczne
wątroba
NOAEL
równanie Abrahama
właściwości fizykochemiczne
Open access
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Creative Commons — Uznanie autorstwa-Niekomercyjne
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Streszczenia
Język
EN
Treść
Objectives Both environmental and occupational exposure limits are based on the no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL) or benchmark dose (BMD) deriving from epidemiological and experimental studies. The aim of this study is to investigate to what extent the NOAEL values for organic compounds responsible for liver toxicity calculated based on their physicochemical properties could be used for calculating occupational exposure limits. Material and Methods The distribution coefficients from air to the liver (log Kliver) were calculated according to the Abraham solvation equation. NOAEL and LOAEL values for early effects in the liver were obtained from the literature data. The descriptors for Abraham??s equation were found for 59 compounds, which were divided into 2 groups: ??non-reactive?? (alcohols, ketones, esters, ethers, aromatic and aliphatic hydrocarbons, amides) and ??possibly reactive?? (aldehydes, allyl compounds, amines, benzyl halides, halogenated hydrocarbons, acrylates). Results The correlation coefficients between log-log K and log NOAEL for non-reactive and reactive compounds amounted to r = ??0.8123 and r = ??0.8045, respectively, and were statistically significant. It appears that the Abraham equation could be used to predict the NOAEL values for compounds lacking information concerning their liver toxicity. Conclusions In view of the tendency to limit animal testing procedures, the method proposed in this paper can improve the practice of setting exposure guidelines for the unstudied compounds.
Inne
System-identifier
100 327 987
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