Elevated brain glucose and glycogen concentrations in an animal model of depression
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
NEUROENDOCRINOLOGY
ISSN
0028-3835
EISSN
1423-0194
Wydawca
KARGER
DOI
Rok publikacji
2014
Numer zeszytu
2-3
Strony od-do
178-190
Numer tomu
100
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Depression;
Prenatal stress;
Glucose;
Glucose transporters;
Insulin receptors;
Corticosterone
Streszczenia
Język
en
Treść
Introduction: Recent data indicate that there is a link between depression and diabetes and that excess glucocorticolds may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations in the hippocampus and frontal cortex in a prenatal stress rat model of depression. Methods: Male rats whose mothers had been subjected to stress and control animals were subjected to the Porsolt test to verify the experimental model. Next, some of the rats were subjected to acute stress and/or were administered glucose. Glucose, glycogen, corticosterone, insulin, insulin receptor, phospho-insulin receptor and glucose transporter (GLUT1, GLUT3 and GLUT4) concentrations were assayed. Results: Prenatally stressed rats exhibited glucose and glycogen concentrations in both investigated brain structures that exceeded those of the control animals. Prenatal stress also in- creased the levels of glucose transporters - GLUT1 in both tissues and GLUT4 in the frontal cortex. The changes in the prenatally stressed rats were more prominent in the animals that were subjected to stress or glucose loading in adulthood. Conclusion: The increase in carbohydrate brain concentrations evoked by prenatal stress may resultfrom changes in the amounts of glucose transporters, especially GLUT1. Moreover, the obtained results support the hypothesis that stress during the perinatal period permanently increases the sensitivity of brain tissue to factors that act in adulthood.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
PX-56989cd3810641ecf9198e6a
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