Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Addiction Biology
ISSN
1355-6215
EISSN
1369-1600
Wydawca
WILEY
DOI
Rok publikacji
2013
Numer zeszytu
2
Strony od-do
307-324
Numer tomu
18
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Cocaine extinction training;
Cocaine self-administration;
in vivo microdialysis;
'yoked' procedure
Streszczenia
Język
en
Treść
We investigated the changes in dopamine (DA), glutamate and -aminobutyric acid (GABA) during cocaine self-administration in rats implanted with guide cannulae into the nucleus accumbens and ventral pallidum. After stabilized cocaine self-administration, separate groups of rats underwent extinction (10 days) procedure in which cocaine infusion was replaced by saline injections. With using a yoked' procedure, the effects of cocaine or its withdrawal on the level of neurotransmitters were evaluated by dual-probe microdialysis. Repeated cocaine administration reduced basal glutamate levels in the nucleus accumbens and ventral pallidum, whereas it did not affect basal accumbal DA levels. Only rats that self-administered cocaine had increased basal GABA overflow in both examined brain structures. Active or passive cocaine administration elevated extracellular accumbal DA, however, the extent of cocaine-evoked DA level was significantly higher in rats that self-administered cocaine while both groups of animals showed also an attenuation of GABA level in the nucleus accumbens. On day 10 of extinction training, rats previously given cocaine revealed decreases in the basal accumbal concentration of glutamate while the basal GABA levels were significantly enhanced as compared with baseline of saline-yoked controls. Potassium depolarization delayed the reduction of the accumbal and pallidal extracellular glutamate levels in the active and passive cocaine groups. The present data indicate that changes in DA and GABA neurotransmission during maintenance phase mirror the motivational aspects of cocaine intake. Depending on acute (24 hours) or late (10 days) cocaine withdrawal, different neurotransmitter systems (i.e. glutamate or GABA) seem to be involved.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
480865
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