Amisulpride promotes cognitive flexibility in rats: The role of 5-HT7 receptors
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
BEHAVIOURAL BRAIN RESEARCH
ISSN
0166-4328
EISSN
1872-7549
Wydawca
ELSEVIER SCIENCE BV
DOI
URL
Rok publikacji
2013
Numer zeszytu
Strony od-do
136-140
Numer tomu
248
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 2)
Słowa kluczowe
en
Amisulpride;
5-HT7 receptor;
5-HT7 agonist;
Set-shifting;
Stress;
Frontal cortex
Streszczenia
Język
en
Treść
The antagonism of 5-HT7 receptors may contribute to the antidepressant and procognitive actions of the atypical antipsychotic drug, amisulpride. It has been previously demonstrated that the selective 5-HT7 receptor antagonist reversed restraint stress-induced cognitive impairments in a rat model of frontal-dependent attentional set-shifting task (ASST). Therefore, the first aim of the present study was to assess the effectiveness of amisulpride against stress-evoked cognitive inflexibility. The second goal was to elucidate whether the pro-cognitive effect of amisulpride could be due to the compound's action at 5-HT7 receptors.Rats repeatedly exposed (1h daily for 7 days) to restraint stress demonstrated impaired performance on the extra-dimensional (ED) set-shifting stage of the ASST. Amisulpride (3mg/kg) given to stressed rats 30min before testing reversed this restraint-induced cognitive inflexibility and improved ED performance of the unstressed control group. The 5-HT7 receptor agonist, AS19 (10mg/kg), abolished the pro-cognitive efficacy of amisulpride (3mg/kg).The present study suggests that the antagonism of 5-HT7 receptors may contribute to the mechanisms underlining the pro-cognitive action of amisulpride. These results may have therapeutic implications in frontal-like deficits associated with stress-related disorders.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
480438
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