Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: An influence of chronic pramipexole in rats
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
PLOS ONE
ISSN
1932-6203
EISSN
Wydawca
PUBLIC LIBRARY SCIENCE
DOI
Rok publikacji
2015
Numer zeszytu
3
Strony od-do
1-17
Numer tomu
10
Identyfikator DOI
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Słowa kluczowe
en
NEUROTROPHIC FACTOR BDNF;
UNPREDICTABLE MILD STRESS;
DEPRESSIVE-LIKE BEHAVIOR;
DEEP BRAIN-STIMULATION;
DORSAL RAPHE NUCLEUS;
SUBSTANTIA-NIGRA;
LATERAL HABENULA;
DENTATE GYRUS;
MOOD DISORDERS;
NIGROSTRIATAL PATHWAY
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Streszczenia
Język
en
Treść
Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour which is reversed by chronic treatment with pramipexole. The purpose of the present study was to examine the role of brain derived neurotrophic factor (BDNF) signalling in the aforementioned model of depression. Therefore, we investigated the influence of 6-hydoxydopamine (6-OHDA) administration into the ventral region of the caudate-putamen on mRNA levels of BDNF and tropomyosin-related kinase B (trkB) receptor. The BDNF and trkB mRNA levels were determined in the nigrostriatal and limbic structures by in situ hybridization 2 weeks after the operation. Pramipexole (1 mg/kg sc twice a day) and imipramine (10 mg/kg ip once a day) were injected for 2 weeks. The lesion lowered the BDNF and trkB mRNA levels in the hippocampus [CA1, CA3 and dentate gyrus (DG)] and amygdala (basolateral/lateral) as well as the BDNF mRNA content in the habenula (medial/lateral). The lesion did not influence BDNF and trkB expression in the caudate-putamen, substantia nigra, nucleus accumbens (shell and core) and ventral tegmental area (VTA). Chronic imipramine reversed the lesion-induced decreases in BDNF mRNA in the DG. Chronic pramipexole increased BDNF mRNA, but decreased trkB mRNA in the VTA in lesioned rats. Furthermore, it reduced BDNF and trkB mRNA expression in the shell and core of the nucleus accumbens, BDNF mRNA in the amygdala and trkB mRNA in the caudate-putamen in these animals. The present study indicates that both the 6-OHDA-induced dopaminergic lesion and chronic pramipexole influence BDNF signalling in limbic structures, which may be related to their pro-depressive and antidepressant activity in rats, respectively.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
PX-56989cd5810641ecf9198f1c
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