Progesterone therapy in women with epilepsy
PBN-AR
Instytucja
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
PHARMACOLOGICAL REPORTS
ISSN
1734-1140
EISSN
Wydawca
ELSEVIER
DOI
Rok publikacji
2013
Numer zeszytu
1
Strony od-do
89-98
Numer tomu
65
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
catamenial epilepsy
progesterone therapy
menstrual cycle
Open access
Tryb otwartego dostępu
Inne
Wersja tekstu w otwartym dostępie
Wersja opublikowana
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Inna
Czas opublikowania w otwartym dostępie
Razem z publikacją
Data udostępnienia w sposób otwarty
Streszczenia
Język
en
Treść
Background: Progesterone with its anti-seizure effect plays a role in the pathophysiology of catamenial epilepsy which affects 31-60\% of epileptic women. In this study, an attempt to treat women suffering from catamenial epilepsy with progesterone, as an adjuvant drug, was made. Methods: The treatment was given to 36 women aged 20-40 years (mean age: 30.75 +/- 6.05) with seizures in the entire second half of the menstrual cycle, who were found to have low serum levels of progesterone on days 22, 27, 28 of the cycle in comparison with a control group of healthy women. The patients were administered progesterone in a daily dose of 50 mg on days 16-25 of each cycle. The serum levels of antiepileptic drugs were assayed. The period of progesterone therapy ranged from 3 to 45 months (17.7 on average). Results: Three patients were free of secondary generalized seizures, and one - of simple partial seizures. A decline in the frequency of primary and secondary generalized seizures by 20-96\% (55.9\% on average) was accomplished in 18 patients (primary generalized by 20-96\%-54.7\% on average, and secondarily generalized by 38-85\%-59\% on average). A decline in the frequency of complex partial seizures by 38-87\% (63.1\% on average) was achieved in 15 women. In 1 patient, the frequency of myoclonic seizures decreased by 46\%. There was no improvement in 5 women (3 patients with generalized, 1 with complex partial and 1 with simple partial seizures). An exacerbation of seizure frequency occurred in 5 patients. Adverse effects were not found in any of the subjects.. The average concentrations of antiepileptic drugs during hormonal therapy were in the therapeutic range. Conclusion: Progesterone combined with antiepileptic therapy was well tolerated and resulted in a significant reduction of seizure frequency in majority of patients with catamenial epilepsy.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
480427
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