Effect of a Static Magnetic Fields and Fluoride Ions on the Antiocidant Defense System of Mice Fibroblast
PBN-AR
Instytucja
Sieć Badawcza Łukasiewicz - Instytut Napędów i Maszyn Elektrycznych KOMEL
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
International Journal of Molecular Sciences
ISSN
1422-0067
EISSN
Wydawca
MDPI AG
DOI
Rok publikacji
2013
Numer zeszytu
14/7/2013
Strony od-do
15017-15028
Numer tomu
Identyfikator DOI
Liczba arkuszy
0,5
Słowa kluczowe
angielski
static magnetic fields (SMF); fluoride; rat fibroblasts; redox homeostasis
Open access
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Po publikacji
Ilość miesięcy od publikacji
1
Streszczenia
Język
angielski
Treść
The results of studies on the biological influence of magnetic fields are controversial and do not provide clear answers regarding their impact on cell functioning. Fluoride compounds are substances that influence free radical processes, which occur when the reactive forms of oxygen are present. It is not known whether static magnetic fields (SMF) cause any changes in fluoride assimilation or activity. Therefore, the aim of this work was to determine the potential relationship between magnetic field exposure to, and the antioxidant system of, fibroblasts cultured with fluoride ions. Three chambers with static magnetic fields of different intensities (0.4, 0.6, and 0.7 T) were used in this work. Fluoride ions were added at a concentration of 0.12 mM, which did not cause the precipitation of calcium or magnesium. The results of this study show that static magnetic fields reduce the oxidative stress caused by fluoride ions and normalize the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). Static magnetic fields modify the energy state of fibroblasts, causing an increase in the ATP concentration and a decrease in the MDA concentration. These results suggest that exposure to fluoride and an SMF improves the tolerance of cells to the oxidative stress induced by fluoride ions.
Inne
System-identifier
PX-5698a314810641ecf919b4b0