Giant Congenital Melanocytic Nevi: Selected Aspects of Diagnostics and Treatment
PBN-AR
Instytucja
Instytut Matki i Dziecka
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Medical Science Monitor
ISSN
1234-1010
EISSN
1643-3750
Wydawca
International Scientific Information, Inc.
DOI
Rok publikacji
2015
Numer zeszytu
brak
Strony od-do
123-132
Numer tomu
21
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Catecholamines
Melanosis
Nevus
Pigmented
Open access
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Creative Commons — Uznanie autorstwa-Niekomercyjne-Bez utworów zależnych
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Razem z publikacją
Streszczenia
Język
en
Treść
Background: Treatment of giant melanocytic nevi (GMN) remains a multidisciplinary challenge. We present analysis of diagnostics, treatment, and follow-up in children with GMN to establish obligatory procedures in these patients. Material/Methods: In 24 children with GMN, we analyzed: localization, main nevus diameter, satellite nevi, brain MRI, catecholamines concentrations in 24-h urine collection, surgery stages number, and histological examinations. The t test was used to compare catecholamines concentrations in patient subgroups. Results: Nine children had ``bathing trunk'' nevus, 7 had main nevus on the back, 6 on head/neck, and 2 on neck/shoulder and neck/thorax. Brain MRI revealed neurocutaneous melanosis (NCM) in 7/24 children (29.2\%), symptomatic in 1. Among urine catecholamines levels from 20 patients (33 samples), dopamine concentration was elevated in 28/33, noradrenaline in 15, adrenaline in 11, and vanillylmandelic acid in 4. In 6 NCM children, all catecholamines concentrations were higher than in patients without NCM (statistically insignificant). In all patients, histological examination of excised nevi revealed compound nevus, with neurofibromatic component in 15 and melanoma in 2. They remain without recurrence/metastases at 8- and 3-year-follow-up. There were 4/7 NCM patients with more than 1 follow-up MRI; in 1 a new melanin deposit was found and in 3 there was no progression. Conclusions: Early excision with histological examination speeds the diagnosis of melanoma. Brain MRI is necessary to confirm/rule-out NCM. High urine dopamine concentration in GMN children, especially with NCM, is an unpublished finding that can indicate patients with more serious neurological disease. Treatment of GMN children should be tailored individually for each case with respect to all medical/psychological aspects.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
599791
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