Key roles of glutamine pathways in reprogramming the cancer metabolism
PBN-AR
Instytucja
Wydział Fizyki (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Oxidative Medicine and Cellular Longevity
ISSN
1942-0900
EISSN
1942-0994
Wydawca
LANDES BIOSCIENCE
DOI
URL
Rok publikacji
2015
Numer zeszytu
Strony od-do
1-14
Numer tomu
10
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
cancer
glutamine
Krebs cycle
tricarboxylic acid cycle
Streszczenia
Język
en
Treść
Glutamine (GLN) is commonly known as an importantmetabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear.However,GLN is themain substrate forDNAand fatty acid synthesis.On the other hand, it reduces the oxidative stress by glutathione synthesis stimulation, stops the process of cancer cachexia, and nourishes the immunological system and the intestine epithelium, as well. The current paper deals with possible positive effects of GLN supplementation and conditions that should be fulfilled to obtain these effects. The analysis of GLN metabolism suggests that the separation of GLN and carbohydrates in the diet can minimize simultaneous supply of ATP (from glucose) and NADPH2 (from glutamine) to cancer cells. It should support to a larger extent the organism to fight against the cancer rather than the cancer cells. GLN cannot be considered the effective source of ATP for cancers with the impaired oxidative phosphorylation and pyruvate dehydrogenase inhibition. GLN intake restores decreased levels of glutathione in the case of chemotherapy and radiotherapy; thus, it facilitates regeneration processes of the intestine epithelium and immunological system.
Cechy publikacji
REVIEW_ARTICLE
Inne
System-identifier
699693
CrossrefMetadata from Crossref logo
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