Effects of liposomes with polyisoprenoids, potential drug carriers, on the cardiovascular and excretory system in rats.
PBN-AR
Instytucja
Instytut Biochemii i Biofizyki Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Pharmacological reports
ISSN
1734-1140
EISSN
Wydawca
Elsevier BV
DOI
Rok publikacji
2014
Numer zeszytu
2
Strony od-do
273-278
Numer tomu
66
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 7
Słowa kluczowe
EN
Drug delivery;
Liposomes;
Polyisoprenoid alcohols;
Renal morphology;
Renal toxicity
Streszczenia
Język
EN
Treść
The unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with. Augmenting the therapeutic efficacy of drugs may prove more fruitful than searching for the new ones. Since recent studies show that new cationic derivatives of polyisoprenoid alcohols (APrens) might exhibit augmenting properties, we intend to use them as a component of liposomal drug carriers. In this study we investigate if these compounds do not per se cause untoward effects on the living organism. METHODS Male Sprague-Dawley rats received for four weeks daily injections (0.5 ml sc) of liposomes built of dioleoyl phosphatidylethanolamine (DOPE), liposomes built of DOPE and APren-7 (ratio 10:1) or water solvent. Weekly, rats were observed in metabolic cages (24h); blood and urine were sampled for analysis; body weight (BW) and systolic blood pressure (SBP) were determined. After chronic experiment, kidneys and heart were harvested for histological and morphometric analysis. RESULTS The 4-week BW increments were in the range of 97 ± 4 to 102 ± 4%, intergroup differences were not significant. Microalbuminuria was the lowest in the group receiving liposomes with APren-7 (0.22 ± 0.03 mg/day). Water and food intake, plasma and urine parameters were similar in all groups. CONCLUSIONS Newly designed liposomes containing APren-7 did not affect functions of the excretory and cardiovascular systems, and renal morphology; therefore we find them suitable as a component of liposomal drug carriers.
Inne
System-identifier
4931
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