The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes
PBN-AR
Instytucja
Wydział Biologii (Uniwersytet Warszawski)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Polish Journal of Microbiology
ISSN
1733-1331
EISSN
Wydawca
POLSKIE TOWARZYSTWO MIKROBIOLOGOW-POLISH SOCIETY OF MICROBIOLOGISTS
DOI
Rok publikacji
2014
Numer zeszytu
1
Strony od-do
21-25
Numer tomu
63
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Listeria monocytogenes
biofilm
listeriolysin O
oleanolic acid
ursolic acid
Streszczenia
Język
en
Treść
Oleanolic acid and ursolic acid are pentacyclic triterpenoids isolated from a variety of medicinal plants, which have antibacterial activity. Listeria monocytogenes is a Gram-positive facultative pathogen, being the causative agent of listeriosis. The present study was carried out to evaluate the in vitro effect of sub-inhibitory concentrations of both triterpene acids on the pathogenicity determinants of L. monocytogenes: their hemolytic activity and biofilm forming ability. Oleanolic and ursolic acids inhibited listeriolysin O activity without influencing toxin secretion. Biofilm formation, and the viability of L. monocytogenes cells in biofilms was diminished by both compounds. Thus, both acids affected L. monocytogenes virulence. It was also demonstrated that oleanolic acid bound to the peptidoglycan of L. monocytogenes and this interaction was influenced by teichoic acids.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
523241