Plasma copeptin for short term risk stratification in acute pulmonary embolism
PBN-AR
Instytucja
Wydział Psychologii (SWPS Uniwersytet Humanistycznospołeczny z siedzibą w Warszawie)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Thrombosis and Thrombolysis
ISSN
1573-742X
EISSN
Wydawca
DOI
URL
Rok publikacji
2015
Numer zeszytu
4
Strony od-do
1-6
Numer tomu
41
Identyfikator DOI
Liczba arkuszy
0.5
Słowa kluczowe
en
Copeptin
Pulmonary embolism
Thromboembolism
Low risk
Streszczenia
Język
en
Treść
Copeptin (COP) was reported to have prognostic value in various cardiovascular diseases. We hypothesized that COP levels reflect the severity of acute pulmonary embolism (PE) and may be useful in prognostic assessment. Plasma COP concentrations were measured on the Kryptor Compact Plus platform (BRAHMS, Hennigsdorf, Germany). The study included 107 consecutive patients with diagnosed acute PE (47 males, 60 females), with median age of 65 years (range 20--88). High risk PE was diagnosed in 3 patients (2.8 , intermediate risk in 69 (64.5 , and low risk PE in 35 (32.7  patients. Control group included 64 subjects (25 males, 39 females; median age 52.5 year, range 17--87). Four patients (3.7  died during 30-day observation. Complicated clinical course (CCC) was experienced by 10 (9.3  patients. COP level was higher in PE patients than in controls [11.55 pmol/L (5.16--87.97), and 19.00 pmol/L (5.51--351.90), respectively, p < 0.0001], and reflected PE severity. COP plasma concentration in low risk PE was 14.67 nmol/L (5.51--59.61) and in intermediate/high risk PE 19.84 mol/L (5.64--351.90) p < 0.05. Median COP levels in nonsurvivors was higher than in survivors, 84.6 (28.48--351.9) pmol/L and 18.68 (5.512--210.1) pmol/L, respectively, p = 0.009. Subjects with CCC presented higher COP levels than patients with benign clinical course 53.1 (17.95--351.9) pmol/L and 18.16 (5.51--210.1) pmol/L, respectively, p = 0.001. Log-transformed plasma COP was the significant predictor of CCC, OR 16.5 95 % CI 23.2--111.9, p < 0.001. AUC---for prediction of CCC using plasma COP was 0.811 (95 % CI 0.676--0.927). The COP cut off value of 17.95 nmol/l had sensitivity of 100  specificity 49.5  positive predictive value of 16.9 % and negative predictive value of 100  We conclude that plasma COP levels can be regarded for promising marker of severity of acute PE and show potential in risk stratification of these patients.
Inne
System-identifier
SWPS6744afc3ef8141d8ba85a6103f252aa1
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