Degradability in vitro of polyurethanes based on synthetic atactic poly[(R,S)-3-hydroxybutyrate]
PBN-AR
Instytucja
Wydział Przedsiębiorczości i Towaroznawstwa (Uniwersytet Morski w Gdyni)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
BIO-MEDICAL MATERIALS AND ENGINEERING
ISSN
0959-2989
EISSN
1878-3619
Wydawca
IOS PRESS
DOI
URL
Rok publikacji
2015
Numer zeszytu
Strony od-do
117-125
Numer tomu
25
Link do pełnego tekstu
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Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 3
Słowa kluczowe
en
Polyurethane
atactic poly[(R
S)-3-hydroxybutyrate]
biomaterial
hydrolytic degradation
oxidative degradation
Streszczenia
Język
en
Treść
The aim of the present study was to determine the degradability of aliphatic polyurethanes, based on a different amount of synthetic, atactic poly[(R,S)-3-hydroxybutyrate] (a-PHB), in hydrolytic (phosphate buffer) and oxidative (H2O2/CoCl2) solutions. The soft segments were built with atactic poly[(R,S)-3-hydroxybutyrate] and polycaprolactone or polyoxytetramethylenediols, whereas hard segments were the reaction product of 4,4?-methylenedicyclohexyl diisocyanate and 1,4-butanediol. The selected properties – density and morphology of polymer surfaces – which could influence the sensitivity of polymers to degradation processes – were analyzed. The analysis of molecular mass (GPC), thermal properties (DSC) and the sample weight changes were undertaken to estimate the degree of degradability of polymer samples after incubation in environments studied. Investigated polyurethanes were amorphous with the very low amount of crystalline phases of hard segments. The polyurethane synthesized with a poly[(R,S)-3-hydroxybutyrate] and polyoxytetramethylenediol at a molar ratio of NCO : OH = 3.7 : 1 (prepolymer step) appeared as the most sensitive for both degradative solutions. Its weight and molecular mass losses were the highest in comparison to other investigated polyurethanes. It could be expected that playing with the amount of poly[(R,S)-3-hydroxybutyrate] in polyurethane synthesis the rate of polyurethane degradation after immersion in living body would be modeled.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
601474
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