APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Experimental Gerontology
ISSN
0531-5565
EISSN
Wydawca
PERGAMON-ELSEVIER SCIENCE LTD
DOI
URL
Rok publikacji
2013
Numer zeszytu
4
Strony od-do
391-394
Numer tomu
48
Identyfikator DOI
Liczba arkuszy
0,56
Słowa kluczowe
en
APBB2
Genetic polymorphisms
Longevity
Centenarians
Severe cognitive impairment
Streszczenia
Język
en
Treść
APBB2 gene encodes for beta-amyloid precursor protein-binding family B member 2, (APBB2, FE65-like, FE65L1), an adaptor protein binding to the cytoplasmatic domain of beta-amyloid precursor protein (beta APP). Over-expression of APBB2 promotes formation of beta-amyloid (A beta), the main constituent of senile plaques. Polymorphisms within APBB2 gene have been proposed as candidate risk factors for Alzheimer's disease. However, their association with longevity has never been investigated. Here we present the first attempt to analyze APBB2 polymorphisms in centenarians. We used a PCR-RFLP method to analyze two intronic nucleotide substitutions: hCV1558625 (rs17443013) and rs13133980. We found no differences in genotype or allele distribution between centenarians and young controls. After stratification of centenarians upon their cognitive performance, the APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability. Also the hCV1558625-rs13133980 AG haplotype increased relative risk for severe cognitive impairment in centenarians. Our results support the concept of APBB2 polymorphism association with cognitive performance in the oldest age. (C) 2013 Elsevier Inc. All rights reserved.
Cechy publikacji
ACCOUNT
Inne
System-identifier
598932
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