Athrombogenic hydrogel coatings for medical devices – Examination of biological properties
PBN-AR
Instytucja
Wydział Inżynierii Chemicznej i Procesowej (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Colloids and Surfaces B-Biointerfaces
ISSN
0927-7765
EISSN
Wydawca
Elsevier BV
DOI
Rok publikacji
2015
Numer zeszytu
Strony od-do
192-198
Numer tomu
130
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
Pozostali autorzy
+ 4
Słowa kluczowe
en
polyurethane, surface modification, blood compatibility, platelet fibrinogen hydrogel
Streszczenia
Język
en
Treść
In the article the authors present hydrogel coatings prepared from polyvinylpyrrolidone (PVP) macromolecules, which are chemically bonded to polyurethane (PU) substrate. The coating is designed to improve the surface hemocompatibility of blood-contacting medical devices. The coating was characterized in terms of physical properties (swelling ratio, hydrogel density, surface morphology, coating thickness, coating durability). In order to examine surface hemocompatibility, the materials were contacted with whole human blood under arterial flow simulated conditions followed by calculation of platelet consumption and the number of platelet aggregates. Samples were also contacted with platelet-poor plasma; the number of surface-adsorbed fibrinogen molecules was measured using ELISA assay. Finally, the inflammatory reaction after implantation was assessed, using New Zealand rabbits. The designed coating is characterized by high water content and excellent durability in aqueous environment – over a 35-day period, no significant changes in coating thickness were observed. Experiments with blood proved twice the reduction in adsorption of serum-derived fibrinogen together with a moderate reduction in the number of platelet aggregates formed during the contact of the material with blood. The analysis of an inflammatory reaction after the implantation confirmed high biocompatibility of the fabricated materials – studies have shown no toxic effects of the implanted material on the surrounding animal tissues.
Inne
System-identifier
WUT12dd39ef2c7144e19070e8d50c9c74aa
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych