Effect of the Restitution Properties of Cardiac Tissue on the Repeatability of Entrainment Mapping Response
PBN-AR
Instytucja
Wydział Fizyki (Politechnika Warszawska)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Circulation-Arrhythmia and Electrophysiology
ISSN
1941-3149
EISSN
Wydawca
Lippincott Williams & Wilkins
DOI
Rok publikacji
2014
Numer zeszytu
3
Strony od-do
497–504
Numer tomu
7
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 3
Słowa kluczowe
en
arrhythmia; catheter ablation; electrophysiology; tachycardia
Streszczenia
Język
en
Treść
BACKGROUND: The difference between the postpacing interval (PPI) and the tachycardia cycle length (TCL; PPI-TCL) is a useful tool in mapping macro-reentrant tachycardias. However, entrainment pacing causes some perturbation of the conduction velocity within the tachycardia circuit, which may affect the repeatability and consequently the accuracy of the measurement of PPI-TCL. The aim of this study was to assess PPI-TCL repeatability both in vivo and in silico. METHODS AND RESULTS: In the experimental part, entrainment pacing was performed twice at each of the 124 tested sites for 30 patients undergoing radiofrequency ablation of atrial and ventricular re-entrant arrhythmias. A similar protocol was used in a simplified computer model of the cardiac tachycardia circuit in a 2-dimensional tissue strip using a Fenton-Karma model of cardiac tissue. In vivo, in the case of fast tachycardias (<350 ms), PPI-TCL variability observed was doubled compared with slow tachycardias (>350 ms; 95% Limits of Agreement ranged from -21.4 to 21.6 ms for TCL<350 ms and from -10.8 to 11.5 ms for TCL>350 ms). Simulations show that this increase of variability may be because of the oscillations of the conduction velocity inside the tachycardia circuits. The effect of the restitution properties of cardiac tissue on the outcome of entrainment pacing is discussed. CONCLUSIONS: PPI-TCL is characterized by a high repeatability with the differences between the results for individual stimulations of ≤20 ms. The variability of this parameter is significantly lower in the case of slow tachycardias.
Inne
System-identifier
WUT295a42094e5a46dc83ab4fc527c293b7
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