Cognitive Performance and Functional Status Are the Major Factors Predicting Survival of Centenarians in Poland
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN
1079-5006
EISSN
1758-535X
Wydawca
OXFORD UNIV PRESS INC
DOI
URL
Rok publikacji
2014
Numer zeszytu
10
Strony od-do
1269-1275
Numer tomu
69
Identyfikator DOI
Liczba arkuszy
0,86
Słowa kluczowe
en
Centenarians
Survival
Mini-Mental State Examination
Katz Activities of Daily Living
Lawton Instrumental Activities of Daily Living
Streszczenia
Język
en
Treść
Background. Clinical and biochemical predictors of extreme longevity would be useful in geriatric practice but have still not been clearly defined. Methods. To identify the best nongenetic predictors of survival in centenarians, we examined 340 individuals aged 100+ years. A detailed questionnaire was completed, and comprehensive geriatric assessment and blood analyses were performed. Survival of study participants was checked annually over the period of 10 years. Results. In the univariate Cox proportional hazards model, a longer survival of centenarians was correlated with a higher adjusted Mini-Mental State Examination (MMSEadj) score (p < .000001), higher Activities of Daily Living (ADL) and adjusted Instrumental Activities of Daily Living (IADL(adj)) scores (p < .000001 and p = .00008, respectively), and younger age at the time of testing (p = .005). Blood pressure, lipid profile, and C-reactive protein and hemoglobin concentrations were not associated with survival. Multivariate analysis including age, sex, and the MMSEadj and ADL scores showed that both MMSEadj and ADL predicted survival (HR = 0.978 per each MMSEadj point, 95\% CI: 0.964-0.993, p = .004; HR = 0.900 per each ADL point, 95\% CI: 0.842-0.962, p = .002, respectively). In multivariate analysis with the ADL score substituted by the IADL(adj) score, the only predictor of survival was MMSEadj (HR = 0.973 per each MMSEadj point, 95\% CI: 0.958-0.988, p = .0006). Conclusions. Cognitive and functional performances are predictors of survival in centenarians.
Cechy publikacji
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Original article
Original article presents the results of original research or experiment.
Inne
System-identifier
PBN-R:591766
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