Cerebrospinal fluid biomarkers of beta-amyloid metabolism and neuronal damage in epileptic seizures
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
European Journal of Neurology
ISSN
1351-5101
EISSN
1468-1331
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2014
Numer zeszytu
3
Strony od-do
486-491
Numer tomu
21
Identyfikator DOI
Liczba arkuszy
0,62
Słowa kluczowe
en
amyloid
heart-type fatty acid binding protein
neuronal injury
seizures
amyloid precursor protein
tau
Streszczenia
Język
en
Treść
Background and purposeThe main objectives of this study were to investigate if epileptic seizures have effects on brain metabolism of -amyloid (A), as reflected by cerebrospinal fluid (CSF) levels of different isoforms of A peptides and soluble amyloid precursor protein (APP), and neuronal degeneration, as reflected by CSF biomarker signs of acute neuronal injury. MethodsForty-five patients were included, 21 of whom had single generalized tonic-clonic seizures sGTCS), 11 had repetitive GTCS, 7 had repetitive partial seizures (rPS), 6 had single partial seizure (sPS) and 4 fulfilled the criterion for non-convulsive status epilepticus (nSE). CSF was analyzed for Ax-38, Ax-40, Ax-42, A1-42, soluble APP fragments (sAPP-/), total-tau (T-tau) and phosphorylated tau (P-tau), as well as heart-type fatty acid binding protein (H-FABP). ResultsPatients with seizures had decreased levels of T-tau (P=0.0016) and P-tau (P=0.0028) compared with controls, but no differences in H-FABP (P=0.67). There were no overall differences in A or sAPP peptides between seizure patients and controls. In patients with rPS, the levels of Ax-38 and Ax-40 were elevated compared with nSE (P<0.01), sPS (P<0.05) and controls (P<0.05), and Ax-42 was elevated in rPS relative to nSE (P<0.05). ConclusionsThe findings of this study argue against acute neuronal injury following medically treated seizures but suggest that seizures may reduce CSF levels of tau. Although seizures generally did not affect CSF levels of A or sAPP peptides, our findings suggest that different types of seizures may have different effects on APP metabolism.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
589350
CrossrefMetadata from Crossref logo
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