Paraoxonase 1 activity and level of antibodies directed against oxidized low density lipoproteins in a group of an elderly population in Poland - PolSenior study
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
0167-4943
EISSN
1872-6976
Wydawca
ELSEVIER IRELAND LTD
DOI
URL
Rok publikacji
2015
Numer zeszytu
1
Strony od-do
153-161
Numer tomu
60
Identyfikator DOI
Liczba arkuszy
1,40
Słowa kluczowe
en
Paraoxonase 1
Anti-oxidized LDL antibodies
Elderly population
Streszczenia
Język
en
Treść
The aim of this study was to assess two factors influencing the amount of oxidized LDL-paraoxonase 1 (PON1) activity and the level of anti-oxidized LDL antibodies (anti-ox LDL) in a large group of elderly individuals in Poland. The effects of cognitive status, hypertension and metabolic syndrome and of selected serum lipids and inflammation indicators on PON1 activity and anti-ox LDL level were also examined. The investigated population consisted of 3154 individuals aged 65 and more - participants of the population-based PolSenior project. PON1 arylesterase activity was determined spectrophotometrically, anti-ox-LDL antibodies using ELISA method. PON1 activity significantly decreased with advancing age, was lower in males than in females and decreased in persons with impaired cognition. Individuals with hypertension and high lipid levels showed higher PON1 activity. Lower PON1 activity was related to higher level of inflammation indicators - hsCRP and IL-6. The significant association of PON1 activity with age, HDL-C, LDL-C, sex and IL-6 was confirmed in multivariate analysis. Anti-ox LDL antibodies level was significantly higher in the two oldest subgroups of males. It was significantly lower in males than in females. It was decreased in persons with higher serum triglycerides. No relationship of anti-ox LDL level with cognition, hypertension, metabolic syndrome, inflammation indicators and serum lipid levels was observed. In some persons very high levels of anti-ox LDL were stated, most frequently in the oldest persons, particularly in men. Conclusion: Both investigated antioxidant factors - PON1 activity and anti-ox LDL level, could play an important role in aging. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
626115
CrossrefMetadata from Crossref logo
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