Age and Gender-Related Changes in Biogenic Amine Metabolites in Cerebrospinal Fluid in Children
PBN-AR
Instytucja
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Advances in Experimental Medicine and Biology
ISSN
0065-2598
EISSN
Wydawca
SPRINGER-VERLAG BERLIN
DOI
URL
Rok publikacji
2016
Numer zeszytu
Strony od-do
73-82
Numer tomu
878
Identyfikator DOI
Liczba arkuszy
0,60
Słowa kluczowe
en
Biogenic amines
Brain metabolism
Cerebrospinal fluid
Children
Gender
Neurotransmitters
Streszczenia
Język
en
Treść
Metabolites of cerebrospinal biogenic amines (dopamine and serotonin) are an important tool in clinical research and diagnosis of children with neurotransmitter disorders. In this article we focused on finding relationships between the concentration of biogenic amine metabolites, age, and gender. We analyzed 148 samples from children with drug resistant seizures of unknown etiology and children with mild stable encephalopathy aged 0–18 years. A normal profile of biogenic amines was found in 107 children and those children were enrolled to the study group. The CSF samples were analyzed by HPLC with an electrochemical detector. The concentrations of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively, were high at birth, gradually decreasing afterward until the 18 years of age. Nevertheless, the HVA/5-HIAA ratio did not vary with age, except in the children below 1 year of age. In the youngest group we observed a strong relationship between the HVA/5-HIAA ratio and age (r = 0.69, p < 0.001). There were no statistical differences in the level of both dopamine and serotonin metabolites between boys and girls, although a trend toward lower HVA and 5-HIAA in the boys was noticeable. Significant inter-gender differences in the level of HVA and 5-HIAA were noted only in the age-group of 1–4 years, with 5-HIAA being higher in the girls than boys (p = 0.004). In conclusion, the study revealed that the concentration of biogenic amine metabolites is age and sex dependent.
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Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Original article
Original article presents the results of original research or experiment.
Inne
System-identifier
PBN-R:660809
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