Similar patterns of infection with bovine foamy virus in experimentally inoculated calves and sheep
PBN-AR
Instytucja
Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF VIROLOGY
ISSN
0022-538X
EISSN
1098-5514
Wydawca
AMER SOC MICROBIOLOGY
DOI
URL
Rok publikacji
2013
Numer zeszytu
6
Strony od-do
3516-3525
Numer tomu
87
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 4)
Pozostali autorzy
+ 2
Słowa kluczowe
en
Bovine Foamy Virus
Infection
Calves
Sheep
Streszczenia
Język
en
Treść
Foamy viruses (FVs) are the least known retroviruses commonly found in primates, cats, horses, and cattle. Although FVs are considered apathogenic, simian and feline FVs have been shown to be associated with some transient health abnormalities in animal models. Currently, data regarding the course of infection with bovine FV (BFV) are not available. In this study, we conducted experimental infections of natural (cattle) and heterologous (sheep) hosts with the BFV100 isolate and monitored infection patterns in both hosts during the early phase postinoculation as well as after long-term infection. Four calves and six sheep inoculated with BFV100 showed no signs of pathology but developed persistent infection, as confirmed by virus rescue, consistent detection of BFV-specific antibodies, and presence of viral DNA. In both hosts, antibodies against BFV Gag and Bet appeared early after infection and persisted at high and stable levels while seroreactivity toward Env was consistently detectable only in BFV-infected sheep. Interestingly, the BFV proviral DNA load was highest in lung, spleen, and liver and moderate in leukocytes, while salivary glands contained either low or undetectable DNA loads in calves or sheep, respectively. Additionally, comparison of partial BFV sequences from inoculum and infected animals demonstrated very limited changes after long-term infection in the heterologous host, clearly less than those found in BFV field isolates. The persistence of BFV infection in both hosts suggests full replication competence of the BFV100 isolate with no requirement of genetic adaptation for productive replication in the authentic and even in a heterologous host.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
552295
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