AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance.
PBN-AR
Instytucja
Wydział Turystyki i Rekreacji (Akademia Wychowania Fizycznego i Sportu im. Jędrzeja Śniadeckiego w Gdańsku)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Experimental Physiology
ISSN
0958-0670
EISSN
1469-445X
Wydawca
WILEY-BLACKWELL
DOI
URL
Rok publikacji
2014
Numer zeszytu
8
Strony od-do
1042-1052
Numer tomu
99
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 26
Słowa kluczowe
en
AGTR2 genotype
Muscle fibre composition
VO2max and sport
Genotype
Endurance
Angiotensin II type 2 receptor
Endurance athletes
Rowers
Kayakers
Speed skaters
pl
Genetyka
Polimorfizm genetyczny
Geny
Sportowcy
Receptor angiotensyny typ 2
Genotyp
Wydolność fizyczna
Mięśnie szkieletowe
Zużycie tlenu
Allele
Łyżwiarstwo szybkie
Wioślarstwo
Kajakarstwo
Immunohistochemia
Analiza statystyczna
Open access
Tryb otwartego dostępu
Otwarte czasopismo
Wersja tekstu w otwartym dostępie
Wersja ostateczna autora
Licencja otwartego dostępu
Inna
Czas opublikowania w otwartym dostępie
Razem z publikacją
Data udostępnienia w sposób otwarty
Streszczenia
Język
en
Treść
New Findings What is the central question of this study? Variations in genes are considered to be molecular determinants maintaining the expression of the slow or fast myosin heavy chains of adult skeletal muscle. The role of polymorphisms of candidate genes involved in skeletal muscle development, energy homeostasis and thyroid and calcium metabolism in the determination of muscle fibre type has not previously been reported. What is the main finding and its importance? We show that the AGTR2 rs11091046 C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance. Such findings have important implications for our understanding of muscle function in both health and disease. Muscle fibre type is a heritable trait and can partly predict athletic success. It has been proposed that polymorphisms of genes involved in the regulation of muscle fibre characteristics may predispose the muscle precursor cells of a given individual to be predominantly fast or slow. In the present study, we examined the association between 15 candidate gene polymorphisms and muscle fibre type composition of the vastus lateralis muscle in 55 physically active, healthy men. We found that rs11091046 C allele carriers of the angiotensin II type 2 receptor gene (AGTR2; involved in skeletal muscle development, metabolism and circulatory homeostasis) had a significantly higher percentage of slow-twitch fibres than A allele carriers [54.2 (11.1) versus 45.2 (10.2)%; P = 0.003]. These data indicate that 15.2% of the variation in muscle fibre composition of the vastus lateralis muscle can be explained by the AGTR2 genotype. Next, we investigated the frequencies of the AGTR2 alleles in 2178 Caucasian athletes and 1220 control subjects. The frequency of the AGTR2 C allele was significantly higher in male and female endurance athletes compared with power athletes (males, 62.7 versus 51.7%, P = 0.0038; females, 56.6 versus 48.1%, P = 0.0169) and control subjects (males, 62.7 versus 51.0%, P = 0.0006; elite female athletes, 65.1 versus 55.2%, P = 0.0488). Furthermore, the frequency of the AGTR2 A allele was significantly over-represented in female power athletes (51.9%) in comparison to control subjects (44.8%, P = 0.0069). We also found that relative maximal oxygen consumption was significantly greater in male endurance athletes with the AGTR2 C allele compared with AGTR2 A allele carriers [n = 28; 62.3 (4.4) versus 57.4 (6.0) ml min−1 kg−1; P = 0.0197]. Taken together, these results demonstrate that the AGTR2 gene C allele is associated with an increased proportion of slow-twitch muscle fibres, endurance athlete status and aerobic performance, while the A allele is associated with a higher percentage of fast-twitch fibres and power-oriented disciplines.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
549224
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