6,6’-Dimethyl-2,2':6',2’-terpyridine revisited: new fluorescent silver(I) helicates with in vitro antiproliferative activity via selective nucleoli targeting
PBN-AR
Instytucja
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
European Journal of Medicinal Chemistry
ISSN
0223-5234
EISSN
Wydawca
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
456-68
Numer tomu
86
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 5
Słowa kluczowe
angielski
Silver(I) helical complex
Terpyridine
Cytotoxicity
Antibacterial activity
Spectroscopic DNA binding experiments
Confocal microscopy
Streszczenia
Język
angielski
Treść
6,6 ''-Dimethyl-2,2':6',2 ''-terpyridine ligand (L) reacts in equimolar ratio with Ag(I) ions what results in formation of dinuclear double helicates, which differ in terms of framework and complexity in accordance to counterions and solvent applied. Obtained complexes were thoroughly studied in terms of their biological activity, with the positive antiproliferative outcome on three human cancer cell lines: human breast cancer (T47D), human cervical carcinoma (HeLa) and human lung cancer (A-549). Performed DNA binding experiments showed that given Ag(I) species specifically interact with DNA double helix via intercalation and were visualized by confocal microscopy to specifically bind to the nuclei. All newly synthesized helical systems exhibit promising antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains. Spectrophotometric properties were described as fulfilment of structural studies of newly presented complexes confirming their helical structure in solution. (C) 2014 Elsevier Masson SAS. All rights reserved.
Inne
System-identifier
553526
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