Phthalocyanine Derivatives Possessing 2-(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy
PBN-AR
Instytucja
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
JOURNAL OF MEDICINAL CHEMISTRY
ISSN
0022-2623
EISSN
Wydawca
AMER CHEMICAL SOC
DOI
URL
Rok publikacji
2015
Numer zeszytu
5
Strony od-do
2240-2255
Numer tomu
58
Identyfikator DOI
Liczba arkuszy
Autorzy
Pozostali autorzy
+ 12
Słowa kluczowe
en
IN-VITRO
ZINC PHTHALOCYANINE
CANCER-CELLS
HELA-CELLS
TETRASULFONATED PHTHALOCYANINES
METAL PHTHALOCYANINES
Streszczenia
Język
en
Treść
Three 2-(morpholin-4-yl)ethoxy substituted phthalocyanines were synthesized and characterized. Phthalocyanine derivatives revealed moderate to high quantum yields of singlet oxygen production depending on the solvent applied (e.g., in DMF ranging from 0.25 to 0.53). Their photosensitizing potential for photodynamic therapy was investigated in an in vitro model using cancer cell lines. Biological test results were found particularly encouraging for the zinc(II) phthalocyanine derivative possessing two 2-(morpholin-4-yl)ethoxy substituents in nonperipheral positions. Cells irradiated for 20 min at 2 mW/cm(2) revealed the lowest IC50 value at 0.25 mu M for prostate cell line (PC3), whereas 1.47 mu M was observed for human malignant melanoma (A375) cells. The cytotoxic activity in nonirradiated cells of novel phthalocyanine was found to be very low. Moreover, the cellular uptake, localization, cell cycle, apoptosis through an ELISA assay, and immunochemistry method were investigated in LNCaP cells. Our results showed that the tested photosensitizer possesses very interesting biological activity, depending on experimental conditions.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
562492
CrossrefMetadata from Crossref logo
Cytowania
Liczba prac cytujących tę pracę
Brak danych
Referencje
Liczba prac cytowanych przez tę pracę
Brak danych