Are KIR genes associated with clinical parameters in the course of periodontitis?
PBN-AR
Instytucja
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Postȩpy Higieny i Medycyny Doświadczalnej
ISSN
EISSN
1732-2693
Wydawca
Instytut Immunologii i Terapii Doświadczalnej, Wrocław
DOI
Rok publikacji
2014
Numer zeszytu
Strony od-do
1145-1151
Numer tomu
68
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 6)
Pozostali autorzy
+ 4
Autorzy przekładu
(liczba autorów przekładu: 0)
Słowa kluczowe
EN
chronic periodontitis
KIR genes
Open access
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Streszczenia
Język
EN
Treść
cells play a role in the pathogenesis of periodontitis. KIRs are a family of inhibitory or activating receptors expressed on the surfaces of NK cells and some subpopulations of T lymphocytes. The aim of this study was to evaluate the impact of KIR genes on the pocket depth (PD) and clinical attachment loss (CAL) parameter values as markers of disease clinical course. The patients in the study were submitted to anamnesis and to clinical and periodontal examination. The subjects (400) were categorized into two groups: periodontitis (250 including 100 with moderate and 140 with severe periodontitis) and controls (150). Both groups were divided into two subgroups: KIR gene positive (presence of KIR gene in the genome) and KIR gene negative (lack of the KIR gene in the genome). The mean value for CAL was more than 5 mm, and the mean value for PD was more than 4 mm in the periodontitis group. The ANOVA test performed for the control group showed that neither PD nor CAL parameters differed between particular KIR-positive and KIR-negative healthy individuals. Similar results were obtained for all subgroups of chronic periodontitis patients and periodontitis patients (moderate as well as severe): no association between KIR genes and PD or CAL parameters was found. The activated immune system is important in pathogenesis of periodontal disease. On the other hand, tissue damage as a response to infection could be due to activation mediated by KIR. In our study no association between either KIR genes presence or absence and PD and CAL parameters was found. Nevertheless, the impact of KIR genes on the clinical course of periodontal disease requires further investigations.
Cechy publikacji
artykuł oryginalny
Inne
System-identifier
PX-563c986a8106caa14734e3ce