A single nucleotide polymorphism rs553668 in the ADRA2A gene and the status of Polish elite endurance athletes
PBN-AR
Instytucja
Wydział Turystyki i Rekreacji (Akademia Wychowania Fizycznego i Sportu im. Jędrzeja Śniadeckiego w Gdańsku)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Trends in Sport Sciences
ISSN
2299-9590
EISSN
Wydawca
Akademia Wychowania Fizycznego w Poznaniu
DOI
Rok publikacji
2013
Numer zeszytu
1
Strony od-do
30-35
Numer tomu
 20
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 3)
Pozostali autorzy
+ 2
Słowa kluczowe
en
ADRA2A gene
rs553668
polymorphism
genetic
elite athletes
pl
Polimorfizm pojedynczego nukleotydu
Genetyka
Sportowcy wysoko kwalifikowani
Allele
Genotyp
Polimorfizm genetyczny
Open access
Tryb otwartego dostępu
Inne
Wersja tekstu w otwartym dostępie
Wersja opublikowana
Licencja otwartego dostępu
Inna
Czas opublikowania w otwartym dostępie
Razem z publikacją
Data udostępnienia w sposób otwarty
Streszczenia
Język
en
Treść
Introduction. The variance in human athletic ability is the result of interaction of both genetic and environmental factors. The ADRA2A gene that encodes adrenergic receptors α2 is likely to be a candidate gene because ADRA2A receptors are crucial for precise cardiovascular control and are involved in the regulation of adipocyte lipolysis, glucose metabolism and insulin secretion. Several genetic variants of the ADRA2A gene have been identifi ed, and one nucleotide polymorphism (SNP) rs553668 seems to be of special importance. On the basis of results of available studies it is assumed that the C allele of rs553668 might be associated with the status of Polish elite endurance athletes. Aim of the Study. The purposes of the study were to determine the distribution of the ADRA2A rs553668 SNP genotypes within a sample of Polish elite endurance athletes and sedentary controls to investigate a possible association between genetic polymorphisms in the ADRA2A gene and elite endurance athlete status and to check for an association between the rs553668 genotypes and alleles and the athlete status. Material and Methods. The study was performed on a group of 123 elite Polish endurance-oriented athletes. Control samples were prepared from 228 unrelated, sedentary volunteers. Results. No statistical differences were found between the endurance athletes and the control group across the ADRA2A C/T genotypes. Similarly, no statistical differences among the subgroups of top-elite, elite and sub-elite endurance athletes were observed. Conclusions. We found that the C allele as well as C-containing genotypes were not significantly more frequent in endurance athletes than in controls. This may suggest that harboring the T allele of the SNP rs553668 allele does not decrease the probability of being an endurance-oriented athlete in the Polish population. In respect to the analyzed popu- lation of Polish endurance athletes the ADRA2A gene can not be considered a candidate determinant of individual variations in exercise-related phenotypes.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
476526