Neuromodulatory action of obestatin on the secretory activity of the hypothalamic-pituitary axis.
PBN-AR
Instytucja
Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Acta Biologica
ISSN
1230-3976
EISSN
2353-3013
Wydawca
Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
DOI
Rok publikacji
2014
Numer zeszytu
Strony od-do
125-134
Numer tomu
21
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 2)
Słowa kluczowe
en
obestatin
central nervous system
hypothalamus
Streszczenia
Język
en
Treść
In 2005, Zhang and co-workers presented information about the new peptide – obestatin. It is a small peptide which is the product of the GHRL gene also responsible for encoding another protein – ghrelin. Obestatin and ghrelin, are produced by post-translational processing of a common precursor preproghrelin and what intriguing characterized by different physiological activity. Obestatin originally has been isolated from cells located in the mucosa of the rat gastric fundus, but successive studies have shown the obestatin presence in other tissues of the body. It was also found that this peptide affinity for the orphan G protein-coupled receptor 39 (GPR39) and receptor for glucagon-like peptide-1 (GLP-1R). As mentioned, obestatin and ghrelin are mainly synthesized by the cells lining the bottom of the stomach. Both peptides are transferred into the blood circulation, where they exhibit an endocrine activity. So far, the information about the obestatin action at the central nervous system (CNS) level are fragmentary and often contradictory. This is due to both, an ambiguous receptor determination and the lack of knowledge about the peptide agonists and antagonists. For this reason, in their deliberations we will focus on obestatin actions in the hypothalamic-pituitary axis.
Cechy publikacji
REVIEW_ARTICLE
Inne
System-identifier
626680