Does central IL-1beta affect GnRH secretion in the hypothalamus of anoestrous ewes via different regulatory pathways?
PBN-AR
Instytucja
Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Animal and Feed Sciences
ISSN
1230-1388
EISSN
Wydawca
THE KIELANOWSKI INSTITUTE OF ANIMAL PHYSIOLOGY AND NUTRITION
DOI
Rok publikacji
2013
Numer zeszytu
1
Strony od-do
5-12
Numer tomu
22
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Ewe
hypothalamus
IL-1b
GnRH
NPY
Streszczenia
Język
en
Treść
ABSTRACT. The study was designed to identify the central pathways through which central interleukin-1β (IL-1β) affects gonadotropin-releasing hormone (GnRH) release in anoestrous ewes. Our results show that intracerebroventricular (icv.) injection of IL-1β (50 μg) decreases the GnRH concentration in the perfusates collected from the medial basal hypothalamus/median eminence (MBH/ME), increases its type I receptor gene expression in the preoptic area, anterior hypothalamus (AHA) and medial basal hypothalamus, and significantly decreases the neuropeptide Y (NPY) mRNA level in the AHA and MBH. No effect of IL-1β treatment was found on plasma cortisol concentration, catecholamine (norepinephrine and dopamine) levels in perfusates, as well as cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) gene expression in the hypothalamus. Our data demonstrate that central IL-1β suppresses GnRH release mainly by acting directly through its own hypothalamic receptors, and its effect could be, at least partially, caused by changes in the NPY level, which is known as an important modulator of GnRH biosynthesis and release.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
625815
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