Investigation of gene-gene interactions between CD40 and CD40L in Polish multiple sclerosis patients
PBN-AR
Instytucja
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Human immunology
ISSN
0198-8859
EISSN
1879-1166
Wydawca
Elsevier/North-Holland
Rok publikacji
2014
Numer zeszytu
8
Strony od-do
796-801
Numer tomu
75
Identyfikator DOI
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Pozostali autorzy
+ 3
Autorzy przekładu
(liczba autorów przekładu: 0)
Słowa kluczowe
EN
CD40
CD40L
Gene–gene interactions
Multiple sclerosis
Streszczenia
Język
EN
Treść
CD40-CD40L interaction is necessary for the activation of both humoral and cellular immune response and has been suggested to play a role in the pathogenesis of multiple sclerosis (MS). Therefore, we analyzed the combined influence of the CD40 and CD40L variants on MS susceptibility and progression on well-defined Polish population. Our investigation revealed that CT individuals in rs1883832 locus of CD40 possessed almost 1.5-fold higher risk for MS than CC individuals (OR = 1.44; 95%CI = 1.03-2.1; p = 0.032), while this risk for TT individuals was almost 2.5-fold higher (OR = 2.36; 95%CI = 1.19-4.78; p = 0.014). Moreover, for the first time, we observed the association of CD40 gene with MS development and progression. We observed that for the rs1883832CC individuals the age at diagnosis was on average 2 years lower than for the rs1883832CT and rs1883832TT individuals (CI95% = -3.69-(-0.29); p = 0.023). Additionally, we detected that individuals with TT and CT genotypes showed lower risk of developing secondary progressive course in comparison to those with CC genotype. For rs1883832TT individuals this risk was 4-fold lower (HR = 0.24; CI95% = 0.10-0.53; p = 0.00062). Despite the fact that CD40-CD40L pathway plays a key role in development of autoimmune diseases, we were not able to detect gene-gene interactions between CD40 and CD40L polymorphisms associated with multiple sclerosis.
Cechy publikacji
artykuł oryginalny
Inne
System-identifier
PX-56b48bcb8106eb71826f820e
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