Electrospinning of gelatin for tissue engineering – molecular conformation as one of the overlooked problems
PBN-AR
Instytucja
Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION
ISSN
0920-5063
EISSN
Wydawca
DOI
Rok publikacji
2014
Numer zeszytu
18
Strony od-do
2009-2022
Numer tomu
25
Identyfikator DOI
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Autorzy
Słowa kluczowe
EN
gelatin
molecular conformation
electrospinning
nanofibers
scaffolds
Streszczenia
Język
EN
Treść
Gelatin is one of the most promising materials in tissue engineering as a scaffold component. This biopolymer indicates biocompatibility and bioactivity caused by the existence of specific amino acid sequences, being preferred sites for interactions with cells, with high similarity to natural extracellular matrix. The present paper does not aspire to be a full review of electrospinning of gelatin and gelatin containing nanofibers as scaffolds in tissue engineering. It is focused on the still open question of the role of the higher order structures of gelatin in scaffold’s bioactivity/functionality. Gelatin molecules can adopt various conformations depending on temperature, solvent, pH, etc. Our review indicates the potential ways for formation of α-helix conformation during electrospinning and the methods of further structure stabilization. It is intuitively expected that the native α-helix conformation appearing as a result of partial renaturation of gelatin can be beneficial from the viewpoint of bioactivity of scaffolds, providing thus a much cheaper alternative approach as opposed to expensive electrospinning of native collagen.
Cechy publikacji
scientific-review
Inne
System-identifier
2503
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