Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: a preliminary study
PBN-AR
Instytucja
Wydział Chemiczny (Politechnika Wrocławska)
Informacje podstawowe
Główny język publikacji
eng
Czasopismo
ENVIRONMENT INTERNATIONAL
ISSN
0160-4120
EISSN
Wydawca
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
71-81
Numer tomu
vol. 68
Identyfikator DOI
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Autorzy
Pozostali autorzy
+ 4
Autorzy przekładu
(liczba autorów przekładu: 0)
Słowa kluczowe
pol
analiza surowicy krwi
ekspozycja na arsen
kadm
ołów
Streszczenia
Język
eng
Treść
Environmental metabonomics is the application of metabonomics to characterize the interactions of organisms with their environment. Metabolic profiling is an exciting addition to the armory of the epidemiologist for the discovery of new disease risk biomarkers and diagnostics. This work is a continuation of research searching for preclinical serum markers in a group of 389 healthy smelter workers exposed to lead, cadmium and arsenic. Changes in the metabolic profiles were studied using Proton Nuclear Magnetic Resonance Spectroscopy on pooled serum samples from both the metal exposed and control groups. These multivariate metabonomic datasets were analyzed with Principal Component Analysis and Partial Least Squares Discriminant Analysis. Analysis of metabolic profiles of people exposed to heavy metals suggests energy metabolism disturbance induced by heavy metals. Changes in lipid fraction (very-low-density lipoprotein — VLDL, low-density lipoprotein — LDL), unsaturated lipids and in the level of amino acids suggest perturbation of the metabolism of lipids and amino acids. This study illustrated the high reliability of NMR-based metabonomic profiling on the study of the biochemical effects induced by the mixture of heavy metals. This approach is capable of identifying intermediate biomarkers of response to toxicants at environmental/occupational concentrations, paving the way to its use in a monitoring of smelter workers exposed to low doses of lead, cadmium and arsenic.
Inne
System-identifier
000192520
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