Engineering of phosphatidylcholine-based solid lipid nanocarriers for flavonoids delivery
PBN-AR
Instytucja
Wydział Chemiczny (Politechnika Wrocławska)
Informacje podstawowe
Główny język publikacji
eng
Czasopismo
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN
0927-7757
EISSN
Wydawca
DOI
URL
Rok publikacji
2014
Numer zeszytu
Strony od-do
483-493
Numer tomu
vol. 460
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
pol
stałe cząstki lipidowe
technika dyfuzyjna
kokrystalizacja
badania strukturalne
Streszczenia
Język
eng
Treść
The present study has been focused on determination and evaluation of three different preparation techniques, i.e., solvent-diffusion, hot homogenization-ultrasonification and microemulsification, applied in fabrication of biocompatible phosphatidylcholine solid lipid nanoparticles ((PC)-SLNs), containing Polawax National Formulary (NF) in the internal lipid phase. The fabricated lipid nanoparticles were loaded with the newly synthesized flavonoid cocrystals, i.e., baicalein–nicotinamide (1:1) (BaiNam), myricetin–piracetam (1:1) (MyrPac) and myricetin–caffeine (1:1) (MyrCaf) cocrystals in relation to the starting flavonoids, differing in solubility and physical state. The assessment of all studied drugs entrapment and availability in aqueous SLN dispersions has been carried out; the size along with size distribution of lipid nanoparticles loaded with the studied flavonoids cocrystals and flavonoids was determined by the DLS technique, while the structural changes—by FT-IR spectroscopy and X-ray powder diffraction (XRPD) of the lipid nanomatrices. XRPD and FT-IR analyses confirmed that parent flavonoids as well as their cocrystals are present in the nanoparticles fabricated with solvent-diffusion method as physical mixtures with the lipid and their crystalline structures at least partially conserved. Summarizing, we designed and fabricated the biocompatible SLN-type nanocarriers of enhanced physical stability and availability for the flavonoids delivery—a vast group of naturally occurring polyphenolic compounds, considered as active pharmaceutical ingredients.
Inne
System-identifier
000191846
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