Expression of Nogo isoforms and Nogo-B receptor (NgBR) in non-small cell lung carcinomas
PBN-AR
Instytucja
Wydział Lekarski (Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
ANTICANCER RESEARCH
ISSN
0250-7005
EISSN
1791-7530
Wydawca
INT INST ANTICANCER RESEARCH
DOI
URL
Rok publikacji
2014
Numer zeszytu
8
Strony od-do
4059-4068
Numer tomu
34
Identyfikator DOI
Liczba arkuszy
Słowa kluczowe
en
Nogo
Nogo-B receptor
non-small cell lung carcinoma
immunohistochemistry
Streszczenia
Język
en
Treść
BACKGROUND: Nogo-B was recently shown to be involved in proliferation, apoptosis and invasiveness of cancer cells, whereas its specific receptor (NgBR) was found to be up-regulated in estrogen receptor-α positive breast cancer. No data are currently available concerning their expression in non-small cell lung carcinomas (NSCLC). MATERIALS AND METHODS: Expression of Nogo isoforms and NgBR was studied in 191 NSCLC. RESULTS: Higher Nogo-A/B immunoreactivity was noted in cancer cells of squamous cell carcinomas (SQC) compared to adenocarcinomas (p<0.001). Stage II-IV tumors had the lowest Nogo-A/B expression (p<0.0001) compared to stage I cases. Nogo-A/B expression decreased with increasing SQC malignancy grade (p=0.026). Significant NgBR mRNA down-regulation was associated with larger primary tumor size (p=0.039), lymph node involvement (p=0.039) and advancement stage (p=0.0054). Low NgBR mRNA expression predicted poor patients outcome (p=0.029). CONCLUSION: The current data may point to the involvement of Nogo isoforms and NgBR in the pathogenesis of NSCLC.
Cechy publikacji
ORIGINAL_ARTICLE
Inne
System-identifier
463103