Antioxidative and anti-inflammatory effects of high beta-glucan concentration purified aqueous extract from oat in experimental model of LPS-induced chronic enteritis
PBN-AR
Instytucja
Wydział Inżynieryjno-Ekonomiczny (Uniwersytet Ekonomiczny we Wrocławiu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Functional Foods
ISSN
1756-4646
EISSN
Wydawca
International Society for Nutraceuticals and Functional Foods
DOI
Rok publikacji
2015
Numer zeszytu
14
Strony od-do
244-254
Numer tomu
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
(liczba autorów: 10)
Pozostali autorzy
+ 9
Słowa kluczowe
en
Blood leucocytes, Enteritis;, Inflammatory process, Lipid peroxidation, Oat beta-glucan, Rat
Streszczenia
Język
en
Treść
Contrary to most of studies concerning oat beta-glucan activity using non-purified oat milling fraction this study investigates aqueous extract of beta-glucan from oat (purity approx. 75%) with high (G1) and low (G2) molecular weight to verified its anti-inflammatory and antioxidant effects in a model of chronic LPS-induced enteritis. Chronic inflammatory bowel diseases, e.g. Crohn's disease (CD) and ulcerative colitis (UC) are expanding with the highest annual CD incidence in North America and the highest annual UC occurrence in Europe. The study has been conducted on Spraque-Dowley rats fed diets supplemented with 1% of G1 or G2 beta-glucan. Obtained results revealed that supplementation with both beta-glucan fractions led to significant reduction of different type blood leucocytes (lymphocytes T and B, granulocytes and lymphocytes Tc). Higher reduction of lipid peroxidation was observed in healthy rats after G1 supplementation, while G2 led this reduction in enteritis groups, mainly due to the increase of antioxidative defense.
Inne
System-identifier
WUT71be1015e47447418e7e25ec556cf658
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