Genetic diagnosis of seronegative (HIV−) partner of female patient with AIDS in the context of HIV transmission
PBN-AR
Instytucja
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Informacje podstawowe
Główny język publikacji
angielski
Czasopismo
HIV & AIDS Review
ISSN
EISSN
Wydawca
Polish AIDS Research Society
Rok publikacji
2016
Numer zeszytu
2
Strony od-do
97–100
Numer tomu
15
Identyfikator DOI
Liczba arkuszy
0,2
Słowa kluczowe
angielski
CCR5-Δ32
HIV transmission
HLA-B
Killer cell immunoglobulin-like receptors
Streszczenia
Język
angielski
Treść
Aim Complex genetic diagnosis of seronegative (HIV−) long-term partner of female patient with AIDS C3 in the context of HIV transmission. Case report and literature review. Background HIV infection was excluded in 47-year-old man, a long-term sexual partner of female patient diagnosed with AIDS C3. The risk of HIV infection was estimated as high. Objective We focused on the genetic diagnosis of serodiscordant couple. We determined the presence of CCR5-Δ32, CCR2-64I, HLA-B, killer cell immunoglobulin-like receptor (KIR) and their ligand genes and human endogenous retroviruses K113 and K115. Methods Genotyping was performed using PCR methods. Results Analysis of partner's genotype revealed the presence of CCR5-Δ32/Δ32 and KIR genes encoding activating receptors (KIR2DS1, 2DS5, 3DS1), features associated with reduced risk of HIV transmission. Similarities in patient's and her partner's HLA (HLA-B*51) and similar inhibitory KIR repertoire and their ligands (KIR2DL1+HLA-C2, KIR2DL3+HLA-C1, KIR3DL1+HLA-B Bw4-80Ile) could favor the transmission of the virus. Conclusion Genetic diagnosis is not routinely recommended, observation of exposed and uninfected individuals would allow to implement new knowledge into more effective care.
Cechy publikacji
case report
Inne
System-identifier
PX-5899bc6a82ce1a20e73ef41b
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