Polymorphisms of DNA repair and oxidative stress genes in B-cell lymphoma patients
PBN-AR
Instytucja
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Biomedical Reports
ISSN
2049-9434
EISSN
2049-9442
Wydawca
Spandidos Publications
DOI
URL
Rok publikacji
2013
Numer zeszytu
1
Strony od-do
151-155
Numer tomu
1
Identyfikator DOI
Liczba arkuszy
0.5
Autorzy
Pozostali autorzy
+ 1
Streszczenia
Język
en
Treść
The purpose of the study was to investigate the possible association between ERCC2 rs28365048, ERCC5 rs17655, XRCC3 rs861539 and NOS2A rs2297518 polymorphisms with B-cell lymphoma. The study was conducted on 189 patients with CD20(+) B-cell lymphoma and 193 controls. The genotype frequencies were compared in the patient and control groups using quantitative polymerase chain reaction, based on allelic discrimination analysis. Our results indicated that variation in NOS2A may be significant in B-cell lymphoma in a population ≥50 years old (OR=2.15; 95% CI, 1.17-3.92; P=0.013). No association was observed between variations in ERCC2, ERCC5, XRCC3 and B-cell lymphoma in the studied population. Our finding of an association between age and NOS2A polymorphisms in lymphoma is unique and requires additional studies. The results concerning ERCC2, ERCC5 and XRCC3 variations add additional data to studies on genetic polymorphisms in the DNA repair pathway.
Inne
System-identifier
COI4821f4969d324cb6afad14106d335ed5
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