Metal accumulation in the human uterus varies by pathology and smoking status
PBN-AR
Instytucja
Wydział Chemii (Uniwersytet im. Adama Mickiewicza w Poznaniu)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Fertility and Sterility
ISSN
0015-0282
EISSN
1556-5653
Wydawca
ELSEVIER SCIENCE INC
DOI
URL
Rok publikacji
2016
Numer zeszytu
6
Strony od-do
1511-1518.e3
Numer tomu
105
Liczba arkuszy
Autorzy
(liczba autorów: 5)
Pozostali autorzy
+ 4
Słowa kluczowe
en
Trace metals
uterine
polyps
bioaccumulation
cigarette smoking
Streszczenia
Język
en
Treść
Objective To evaluate the content of Al, Cd, Cr, Cu, Mn, Ni, Pb, and Zn in human endometrium (END), endocervix (ECX), and endometrial (END-P) and endocervical (ECX-P) polyps in relation to histologic image and female demographic characteristics and habits. Design Tissues were collected during curettage of the uterine cavity, subjected to histopathologic examination, digested, and analyzed with the use of a microwave induced nitrogen plasma atomic emission spectrometer. Demographic/lifestyle characteristics were assessed with the use of a questionnaire. Setting University hospital and research laboratory. Patient(s) One hundred nine white Polish women undergoing curettage of the END (n = 60) or ECX (n = 23) or dissection of END-P (n = 16) or ECX-P (n = 10). Interventions(s) None. Main Outcome Measure(s) Trace element concentrations in collected tissues. Result(s) Histologic states of analyzed END included: normal (n = 22), irregularity (n = 3), polypoid (n = 12), simple hyperplasia (n = 10), leiomyoma (n = 5), and cancer (n = 8); whereas for ECX: normal (n = 10), inflammation (n = 8), irregularity (n = 2), and cervical intraepithelial neoplasia (CIN; n = 3). All elements were identified in the sampled material. Compared with histologically normal tissues, endometrial cancer, hyperplasia, and CIN revealed significantly increased levels of toxic metals (Cd and Pb), altered status of Cu and Mn, and an elevated Cu/Zn ratio. Current and former smoking was associated with significantly higher Cd and Pb levels in investigated tissues. Polyps represented significant accumulators of Al, Cd, Ni, and Pb (END-P) or Al, Cd, and Cu (ECX-P). Conclusion(s) The findings of this study are important in understanding the presence and role of metals in the female reproductive system and its pathology. © 2016 American Society for Reproductive Medicine
Cechy publikacji
Original article
Original article presents the results of original research or experiment.
Oryginalny artykuł naukowy
Oryginalny artykuł naukowy przedstawia rezultaty oryginalnych badań naukowych lub eksperymentu.
Inne
System-identifier
PBN-R:773768
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