Biopolymeric hydrogels − nanostructured $TiO_{2}$ hybrid materials as potential injectable scaffolds for bone regeneration
PBN-AR
Instytucja
Wydział Inżynierii Materiałowej i Ceramiki (Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie)
Informacje podstawowe
Główny język publikacji
EN
Czasopismo
Colloids and Surfaces. B, Biointerfaces
ISSN
0927-7765
EISSN
1873-4367
Wydawca
Elsevier Science BV
DOI
Rok publikacji
2016
Numer zeszytu
Strony od-do
607--614
Numer tomu
148
Link do pełnego tekstu
Identyfikator DOI
Liczba arkuszy
0.57
Autorzy
Pozostali autorzy
+ 3
Słowa kluczowe
EN
scaffolds
bioactivity
titanium dioxide
chitosan
collagen
hydrogels
Streszczenia
Język
EN
Treść
The present work aims at development of novel hybrid materials from genipin crosslinked collagen or collagen/chitosan hydrogels containing various types of TiO2 nanoparticles characterized with different anatase/rutile ratios. Collagen and chitosan were selected as hydrogel components since they are biopolymers being, like collagen, the major compound present in extracellular matrix or exhibit structural similarity to glycosaminoglycans, like chitosan. TiO2 nanoparticles were introduced to the hydrogel matrices to improve their mechanical properties as well as bioactivity. A series of twelve novel hybrid materials were prepared and their physicochemical, mechanical and biological properties were evaluated. It was found that TiO2 nanostructures introduced to the hydrogels have significant influence on the swelling properties of the synthesized hybrids and their impact is strongly dependent on the type of matrices. The surfaces of hybrid materials were found to be more hydrophilic than these of corresponding hydrogel matrix. It was also observed that, the storage modulus values of the hybrids based on collagen-chitosan hydrogel are comparable to these for plain hydrogels what indicates that the mechanical properties of the materials obtained are satisfactory for possible biomedical application. The in vitro cell culture studies have shown that prepared materials are biocompatible as they can support mitochondrial activity of MEFs as well as MG-63 cells. In vitro experiments performed under simulated body fluid (SBF) conditions have revealed that all studied TiO2 nanoparticles present in hydrogel matrices, regardless of anatase/rutile ratio, successfully induced formation of apatite-like structures. The hybrid materials developed here are promising candidates for preparation of bioactive, injectable scaffolds for tissue engineering. © 2016 Elsevier B.V.
Cechy publikacji
original article
peer-reviewed
Inne
System-identifier
idp:101590
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