Inhibitory effect of alloferons in combination with human lymphocytes on human herpesvirus 1 (HHV-1) replication.
PBN-AR
Instytucja
Wydział Chemii (Uniwersytet Wrocławski)
Informacje podstawowe
Główny język publikacji
en
Czasopismo
International Journal of Peptide Research and Therapeutics
ISSN
1573-3149
EISSN
1573-3904
Wydawca
Springer, New York
Rok publikacji
2016
Numer zeszytu
Strony od-do
255-261
Numer tomu
22
Identyfikator DOI
Liczba arkuszy
Autorzy
(liczba autorów: 4)
Pozostali autorzy
+ 3
Słowa kluczowe
en
Alloferon
Antiviral activity
Herpesvirus
HHV-1
Insect peptides
Virus replication
Streszczenia
Język
en
Treść
Over the past two decades there has been intense study of compounds from vertebrates, microor-ganisms, plants, mushrooms, marine sponges, worms, etc. as well as insects in terms of their antiviral activity. Insectsproduce a variety of biologically active peptides. One of them is alloferon. The in vitro and in vivo experimentsdemonstrate that synthetic alloferon has an immunomod-ulatory properties. It was reported that alloferon and itsanalogues (alloferon I and II) have antimicrobial properties, as well. The aim of this study was to evaluate in vitrothe effect of alloferon I and II, either alone or in combination with human lymphocytes, on human herpesvirustype 1 (HHV-1) McIntyre strain replication. On the base of results we can conclude that alloferon I and II inhibit thereplication of HHV-1 McIntyre strain in HEp-2 cells. Enhanced antiviral activity was observed when infectedcells were treated with alloferons and unstimulated or phytohemagglutinin PHA-stimulated lymphocytes simul-taneously. After application of alloferons and PHA-stimulated lymphocytes to the HHV-1 infected HEp-2 culture,the mean HHV-1 titer reduction for alloferon and II, when used at the highest dose—400µgmL, were 3.69 and 3.27log10/TCID50/mL,respectively.
Cechy publikacji
original-article
Inne
System-identifier
2016CH7938
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