Bone regeneration potential of the new chitosan alloplastic biomaterial
PBN-AR
Instytucja
Narodowy Instytut Leków
Informacje podstawowe
Główny język publikacji
en
Czasopismo
Journal of Biomaterials Applications
ISSN
0885-3282
EISSN
Wydawca
SAGE PUBLICATIONS LTD
DOI
URL
Rok publikacji
2013
Numer zeszytu
7
Strony od-do
38-48
Numer tomu
28
Link do pełnego tekstu
Identyfikator DOI
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Autorzy
(liczba autorów: 6)
Pozostali autorzy
+ 4
Słowa kluczowe
en
alginate
bone substitute material
chitosan
guided bone regeneration
β-tricalcium phosphate
rat model
Streszczenia
Język
en
Treść
Over the last few years, alloplastic bone substitute materials are raising much interest as an alternative to autologic transplants and xenogenic materials especially in oral surgery. These non-immunogenic and completely resorbable biomaterials are becoming the basis for complete and predictable guided bone regeneration in many cases. The objective of our research was to evaluate the dynamics of bone formation in rats' skulls after implantation of the new chitosan/tricalcium phosphate/alginate biomaterial in comparison to the commercially available alloplastic bone graft. A total of 45 adult male rats weighing 300-400 g were used for the study. The 85-mm-diameter defects in calvaria bone were prepared with a trephine bur, and then filled with the bone substitute materials: chitosan/tricalcium phosphate/alginate or easy-graft Classic (Degradable Solutions AG) (EA) or left just with the blood clot. Animals were sacrificed at 1 and 3 months for histological, histomorphometrical and micro-tomographic evaluations. Histological evaluation at 1 month showed early new bone formation, observed around the experimental biomaterial (CH/TCP/Alg). There were no features of purulent inflammation and necrosis or granulomatous inflammation. Microscopic examination after 3 months following the surgery revealed trabecular bone formation around chitosan-based bone graft with no significant inflammatory response. Less satisfactory and differing results were observed for the commercially available EA and control blood clot. The tested material (chitosan) showed a high degree of biocompatibility and osteoconductivity in comparison with the control groups. Additionally, it seemed to be a "user-friendly" material for oral surgeons.
Inne
System-identifier
PX-56b45b298106eb71826df51f
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